Orioles vs. Guardians Predictions & Picks: Odds, Moneyline, Spread - September 21

Thursday's contest that pits the Baltimore Orioles (95-57) versus the Cleveland Guardians (72-81) at Progressive Field should be a competitive matchup based on our computer prediction, which projects a final score of 6-4 in favor of the Orioles. Game time is at 7:15 PM ET on September 21.

The Orioles will call on Grayson Rodriguez (6-4) against the Guardians and Hunter Gaddis (2-1).

Orioles vs. Guardians Game Info & Odds

• When: Thursday, September 21, 2023 at 7:15 PM ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: FOX
• Live Stream: Watch this game on Fubo!

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Orioles vs. Guardians Score Prediction

Our pick for this game is Orioles 6, Guardians 5.

Total Prediction for Orioles vs. Guardians

• Total Prediction: Over 8 runs

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• How to Watch Orioles vs Guardians

Orioles Performance Insights

• The Orioles have played as the favorite in six of their past 10 games and have gone 2-4 in those contests.
• When it comes to hitting the over, Baltimore and its opponents are 4-5-1 in its last 10 games with a total.
• The Orioles have not played a game with a spread over their last 10 outings.
• This season, the Orioles have won 51 out of the 75 games, or 68%, in which they've been favored.
• Baltimore is 24-8 this season when entering a game favored by -160 or more on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Orioles have a 61.5% chance to win.
• Baltimore has scored the sixth-most runs in the majors this season with 776.
• The Orioles have a 4.01 team ERA that ranks 10th among all MLB pitching staffs.

Guardians Performance Insights

• In five games as the underdog over the last 10 matchups, the Guardians have a record of 3-2.
• In its last 10 games with an over/under, Cleveland and its opponents have combined to eclipse the total six times.
• The past 10 Guardians games have not had a spread posted by bookmakers.
• The Guardians have been chosen as underdogs in 73 games this year and have walked away with the win 32 times (43.8%) in those games.
• This season, Cleveland has come away with a win seven times in 20 chances when named as an underdog of at least +135 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 42.6% chance of pulling out a win.
• Cleveland scores the fourth-fewest runs in baseball (626 total, 4.1 per game).
• The Guardians have pitched to a 3.95 ERA this season, which ranks seventh in baseball.

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Orioles Schedule

Guardians Schedule