Thursday's contest that pits the Baltimore Orioles (95-57) versus the Cleveland Guardians (72-81) at Progressive Field should be a competitive matchup based on our computer prediction, which projects a final score of 6-4 in favor of the Orioles. Game time is at 7:15 PM ET on September 21.

The Orioles will call on Grayson Rodriguez (6-4) against the Guardians and Hunter Gaddis (2-1).

Orioles vs. Guardians Game Info & Odds

  • When: Thursday, September 21, 2023 at 7:15 PM ET
  • Where: Progressive Field in Cleveland, Ohio
  • How to Watch on TV: FOX
  • Live Stream: Watch this game on Fubo!

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Orioles vs. Guardians Score Prediction

Our pick for this game is Orioles 6, Guardians 5.

Total Prediction for Orioles vs. Guardians

  • Total Prediction: Over 8 runs

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Read More About This Game

Orioles Performance Insights

  • The Orioles have played as the favorite in six of their past 10 games and have gone 2-4 in those contests.
  • When it comes to hitting the over, Baltimore and its opponents are 4-5-1 in its last 10 games with a total.
  • The Orioles have not played a game with a spread over their last 10 outings.
  • This season, the Orioles have won 51 out of the 75 games, or 68%, in which they've been favored.
  • Baltimore is 24-8 this season when entering a game favored by -160 or more on the moneyline.
  • Oddsmakers have implied with the moneyline set for this matchup that the Orioles have a 61.5% chance to win.
  • Baltimore has scored the sixth-most runs in the majors this season with 776.
  • The Orioles have a 4.01 team ERA that ranks 10th among all MLB pitching staffs.

Guardians Performance Insights

  • In five games as the underdog over the last 10 matchups, the Guardians have a record of 3-2.
  • In its last 10 games with an over/under, Cleveland and its opponents have combined to eclipse the total six times.
  • The past 10 Guardians games have not had a spread posted by bookmakers.
  • The Guardians have been chosen as underdogs in 73 games this year and have walked away with the win 32 times (43.8%) in those games.
  • This season, Cleveland has come away with a win seven times in 20 chances when named as an underdog of at least +135 or worse on the moneyline.
  • Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 42.6% chance of pulling out a win.
  • Cleveland scores the fourth-fewest runs in baseball (626 total, 4.1 per game).
  • The Guardians have pitched to a 3.95 ERA this season, which ranks seventh in baseball.

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Orioles Schedule

Date Opponent Score Pitching Matchup
September 16 Rays W 8-0 Grayson Rodriguez vs Tyler Glasnow
September 17 Rays W 5-4 Dean Kremer vs Zack Littell
September 18 @ Astros W 8-7 John Means vs Justin Verlander
September 19 @ Astros W 9-5 Kyle Gibson vs Hunter Brown
September 20 @ Astros L 2-1 Kyle Bradish vs Cristian Javier
September 21 @ Guardians - Grayson Rodriguez vs Hunter Gaddis
September 22 @ Guardians - Dean Kremer vs Shane Bieber
September 23 @ Guardians - John Means vs Cal Quantrill
September 24 @ Guardians - Kyle Gibson vs Logan Allen
September 26 Nationals - Kyle Bradish vs Jackson Rutledge
September 27 Nationals - Grayson Rodriguez vs Josiah Gray

Guardians Schedule

Date Opponent Score Pitching Matchup
September 16 Rangers W 2-1 Tanner Bibee vs Dane Dunning
September 17 Rangers W 9-2 Gavin Williams vs Cody Bradford
September 18 @ Royals L 6-4 Cal Quantrill vs Brady Singer
September 19 @ Royals L 7-6 Logan Allen vs Steven Cruz
September 20 @ Royals L 6-2 Lucas Giolito vs Zack Greinke
September 21 Orioles - Hunter Gaddis vs Grayson Rodriguez
September 22 Orioles - Shane Bieber vs Dean Kremer
September 23 Orioles - Cal Quantrill vs John Means
September 24 Orioles - Logan Allen vs Kyle Gibson
September 26 Reds - Lucas Giolito vs TBA
September 27 Reds - TBA vs Hunter Greene