Democrat is first candidate to declare for Wyoming US Senate
The 49-year-old Ludwig will be announcing her candidacy for the party's nomination on Friday in Laramie, where she has lived since moving to the state in 2016.
In an interview Wednesday with the Casper Star-Tribune, Ludwig said her campaign will be focused on elevating issues like economic insecurity and climate change that can only be addressed at the national level.
A newcomer to politics, Ludwig has been a vocal presence in the Laramie community and considers herself a socialist on economic issues.
Enzi announced in May that he would retire from the Senate when his current term expires.